17,217 research outputs found
The interaction of amyloid A beta(1-40) with lipid bilayers and ganglioside as studied by P-31 solid-state NMR
Amyloid P-peptide (A beta) is a major component of plaques in Alzheimer's disease, and formation of senile plaques has been suggested to originate fro m regions of neuronal membrane rich in gangliosides. We analyzed the mode of interaction of A beta with lipid bilayers by multinuclear NMR using P-31 nuclei. We found that A beta (1-40) strongly perturbed the bilayer structure of dimyristoylphosphatidylcholine (DMPQ, to form a non-lamellar phase (most likely micellar). The ganglioside GM1 potentiated the effect of A beta (1-40), as viewed from P-31 NMR. The difference of the isotropic peak intensity between DMPC/A beta and DMPC/GM1/A beta suggests a specific interaction between A beta and GM1. We show that in the DMPC/GM1/A beta system there are three lipid phases, namely a lamellar phase, a hexagonal phase and non-oriented lipids. The latter two phases are induced by the presence of the A beta peptide, and facilitated by GM1. 9) 2008 Elsevier Ireland Ltd. All rights reserved
Anomalous Radio-Wave Scattering from Interstellar Plasma Structures
This paper considers scattering screens that have arbitrary spatial
variations of scattering strength transverse to the line of sight, including
screens that are spatially well confined, such as disks and filaments. We
calculate the scattered image of a point source and the observed pulse shape of
a scattered impulse. The consequences of screen confinement include: (1) Source
image shapes that are determined by the physical extent of the screen rather
than by the shapes of much-smaller diffracting microirregularities. These
include image elongations and orientations that are frequency dependent. (2)
Variation with frequency of angular broadening that is much weaker than the
trademark \nu^{-2} scaling law (for a cold, unmagnetized plasma), including
frequency-independent cases; and (3) Similar departure of the pulse broadening
time from the usually expected \nu^{-4} scaling law. We briefly discuss
applications that include scattering of pulses from the Crab pulsar by
filaments in the Crab Nebula; image asymmetries from Galactic scattering of the
sources Cyg X-3, Sgr A*, and NGC 6334B; and scattering of background active
galactic nuclei by intervening galaxies. We also address the consequences for
inferences about the shape of the wavenumber spectrum of electron density
irregularities, which depend on scaling laws for the image size and the pulse
broadening. Future low-frequency (< 100 MHz) array observations will also be
strongly affected by the Galactic structure of scattering material. Our
formalism is derived in the context of radio scattering by plasma density
fluctuations. It is also applicable to optical, UV and X-ray scattering by
grains in the interstellar medium.Comment: 21 pages, LaTeX2e with AASTeX-4.0, 6 PostScript figures, accepted by
ApJ, revised version has minor changes to respond to referee comments and
suggestion
Root system architecture determines fitness in an Arabidopsis mutant in competition for immobile phosphate ions but not for nitrate ions
Plant root systems often have complex branching patterns. Models indicate that a complex architecture is only required for the acquisition of immobile resources, such as phosphate; mobile ions, notably nitrate, can be effectively taken up by very restricted root systems. We have tested this prediction using the axr4 mutation of Arabidopsis thaliana, the principal phenotypic effect of which is to reduce the number of lateral roots. Arabidopsis thaliana is not a host for mycorrhizal fungi and so acquires all its nutrients through the root system. In both a pot experiment and a field experiment conducted under natural conditions for A. thaliana, we found that only phosphate, and not nitrate, affected the fitness of the mutant relative to the isogenic wild-type line, Columbia. These results confirm model predictions and have implications both for the evolution of complex root systems and for the design of efficient root systems for crops
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Application of NDT thermographic imaging of aerospace structures
This work aims to address the effectiveness and challenges of Non-Destructive Testing (NDT) inspection and improve the detection of defects without causing damage to the material or operator. It focuses on two types of NDT methods; pulsed thermography and vibrothermography. The paper also explores the possibility of performing automated aerial inspection using an unmanned aerial vehicle (UAV) provided with a thermographic imaging system. The concept of active thermography is discussed for inspecting aircraft CFRP panels along with the proposal for performing aerial inspection using the UAV for real time inspection. Static NDT results and the further UAV research indicate that the UAV inspection approach could significantly reduce the inspection time, cost, and workload, whilst potentially increasing the probability of detection
Non-Gaussian Radio-Wave Scattering in the Interstellar Medium
It was recently suggested by Boldyrev & Gwinn that the characteristics of
radio scintillations from distant pulsars are best understood if the
interstellar electron-density fluctuations that cause the time broadening of
the radio pulses obey non-Gaussian statistics. In this picture the density
fluctuations are inferred to be strong on very small scales (). We argue that such density structures could correspond to the ionized
boundaries of molecular regions (clouds) and demonstrate that the power-law
distribution of scattering angles that is required to match the observations
arises naturally from the expected intersections of our line of sight with
randomly distributed, thin, approximately spherical ionized shells of this
type. We show that the observed change in the time-broadening behavior for
pulsar dispersion measures is consistent
with the expected effect of the general ISM turbulence, which should dominate
the scattering for nearby pulsars. We also point out that if the clouds are
ionized by nearby stars, then their boundaries may become turbulent on account
of an ionization front instability. This turbulence could be an alternative
cause of the inferred density structures. An additional effect that might
contribute to the strength of the small-scale fluctuations in this case is the
expected flattening of the turbulent density spectrum when the eddy sizes
approach the proton gyroscale.Comment: 15 pages, 3 figures, accepted to Ap
Simultaneous Dual Frequency Observations of Giant Pulses from the Crab Pulsar
Simultaneous measurements of giant pulses from the Crab pulsar were taken at
two widely spaced frequencies using the real-time detection of a giant pulse at
1.4 GHz at the Very Large Array to trigger the observation of that same pulse
at 0.6 GHz at a 25-m telescope in Green Bank, WV. Interstellar dispersion of
the signals provided the necessary time to communicate the trigger across the
country via the Internet. About 70% of the pulses are seen at both 1.4 GHz and
0.6 GHz, implying an emission mechanism bandwidth of at least 0.8 GHz at 1 GHz
for pulse structure on time scales of one to ten microseconds.
The arrival times at both frequencies display a jitter of 100 microseconds
within the window defined by the average main pulse profile and are tightly
correlated. This tight correlation places limits on both the emission mechanism
and on frequency dependent propagation within the magnetosphere.
At 1.4 GHz the giant pulses are resolved into several, closely spaced
components. Simultaneous observations at 1.4 GHz and 4.9 GHz show that the
component splitting is frequency independent. We conclude that the multiplicity
of components is intrinsic to the emission from the pulsar, and reject the
hypothesis that this is the result of multiple imaging as the signal propagates
through the perturbed thermal plasma in the surrounding nebula. At both 1.4 GHz
and 0.6 GHz the pulses are characterized by a fast rise time and an exponential
decay time which are correlated. The pulse broadening with its exponential
decay form is most likely the result of multipath propagation in intervening
ionized gas.Comment: LaTeX, 18 pages, 7 figures, accepted for publication in The
Astrophysical Journa
A taxonomy of errors for information systems
We provide a full characterization of computational error states for information systems. The class of errors considered is general enough to include human rational processes, logical reasoning, scientific progress and data processing in some functional programming languages. The aim is to reach a full taxonomy of error states by analysing the recovery and processing of data. We conclude by presenting machine-readable checking and resolve algorithms
The automated detection of proliferative diabetic retinopathy using dual ensemble classification
Objective: Diabetic retinopathy (DR) is a retinal vascular disease that is caused by complications of diabetes. Proliferative diabetic retinopathy (PDR) is the advanced stage of the disease which carries a high risk of severe visual impairment. This stage is characterized by the growth of abnormal new vessels. We aim to develop a method for the automated detection of new vessels from retinal images.
Methods: This method is based on a dual classification approach. Two vessel segmentation approaches are applied to create two separate binary vessel maps which each hold vital information. Local morphology, gradient and intensity features are measured using each binary vessel map to produce two separate 21-D feature vectors. Independent classification is performed for each feature vector using an ensemble system of bagged decision trees. These two independent outcomes are then combined to a produce a final decision.
Results: Sensitivity and specificity results using a dataset of 60 images are 1.0000 and 0.9500 on a per image basis.
Conclusions: The described automated system is capable of detecting the presence of new vessels
Extracting molecular Hamiltonian structure from time-dependent fluorescence intensity data
We propose a formalism for extracting molecular Hamiltonian structure from
inversion of time-dependent fluorescence intensity data. The proposed method
requires a minimum of \emph{a priori} knowledge about the system and allows for
extracting a complete set of information about the Hamiltonian for a pair of
molecular electronic surfaces.Comment: 7pages, no figures, LaTeX2
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